Neuronal nAChR stereoselectivity to non-natural epibatidine derivatives
نویسندگان
چکیده
منابع مشابه
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15 صفحه اول[125I]IPH, an epibatidine analog, binds with high affinity to neuronal nicotinic cholinergic receptors.
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متن کاملSynthesis of (-)-epibatidine.
The synthesis of (-)-epibatidine has been accomplished utilizing a highly exo-selective asymmetric hetero Diels-Alder reaction. The key steps employed to transform the resulting bicycle into the natural product include a fluoride-promoted fragmentation and a Hofmann rearrangement. Reaction: see text.
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1999
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(99)00473-1